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Intramuscular replacement therapy is indicated for patients with: Significant B12 deficiency (thresholds depend on local laboratory reference ranges) Neurological symptoms or signs Pernicious anaemia Malabsorption syndromes The standard UK regimen for patients without neurological involvement involves hydroxocobalamin 1mg intramuscularly three times weekly for two weeks, followed by maintenance injections every 2-3 months (often 3-monthly)

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Neurological Ageing Both compounds have neurological ageing research relevance through distinct mechanisms: GHK-Cu through Nrf2-mediated neuroprotection (MDA/8-OHdG reduction in aged neurones, BDNF upregulation through NF-κB cross-regulation, neuroinflammation reduction) and Epitalon through NSC telomere maintenance (SGZ neurogenesis preservation, hippocampal volume maintenance with ageing)