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For instance, CTAP, a penta-amine derivative, demonstrated 100-fold higher transfection efficiency than conventional DC-Chol/DOPE formulations due to the high charge density of fully protonated polyamines at physiological pH, enabling efficient NA neutralization and condensation [89]

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The BSO model also provides a uniquely sensitive model to CS exposure, which actually necessitated a lower CS particulate concentration during the exposure (∼80 mg/m 3 ), in comparison to the upward trend in the literature of vastly higher levels of smoke (∼300 mg/m 3 ) to achieve evidence of lung inflammation and airspace enlargement