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As a result, a new ferroptosis inhibition axis with GTP cyclohydrolase-1 (GCH1) as the core was finally determined, which was found to be mainly regulated by the GCH1/BH4/DHFR pathway, which also protected cells from ferroptosis in a GPX4-independent manner (49, 50) ( Figure 1D )
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Among these, 29 CGs were predicted to be associated with localization, transport, and transmembrane transport, including OsPDR8 , OsPDR9 , OsPDR10 , OsNRAMP6 , OsPT2 , OsZIP8 , OsTIP2;2 , OsFRDL2 , OsPEZ1 , OsMATE35 , OsHMP18 , OsHMP39 , SWEET6A , OsNRT1.5 A , OsMST4 , OsPUP2 , and OsPUP3 , among others
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