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In addition, a phase 1 trial is currently underway to test an GCN2 activator, HC-7366, in AML (142)
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high soluble fiber intake in dysbiotic mice induced cholestatic HCC via dysregulated microbial fermentation and altered BA homeostasis (134), while a high-fat, high-cholesterol diet post-cholecystectomy exacerbated BA dysregulation and intestinal inflammation (144)
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