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What every physician needs to know about peptide therapy
A direct correlation between the efficiency of receptor phosphorylation and an agonist’s efficacy is consistent with evidence suggesting that G βγ is a cofactor necessary for maximal GRK activation (DebBurman et al., 1996), although it is also likely that differences in agonist-induced conformational changes affect the accessibility of specific phosphorylation sites in the receptor
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Davignon JL, Hayder M, Baron M, Boyer JF, Constantin A, Apparailly F et al
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