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Under normal conditions, NRF2 is tightly suppressed by Kelch-like ECH-associated protein 1 (KEAP1), which mediates NRF2 degradation through ubiquitination (Kobayashi et al., 2004)
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6 Future perspective Although significant advances have been made in deciphering the link between ferroptosis and neuroinflammation, a number of challenges still exist before ferroptosis-modulating therapies can be successfully applied in the clinic
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