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The Cys 36 residue in GpoA is encoded by a UGU codon, however, GpoA present a SECIS element identified in silico immediately after this codon that suggest an evolution from selenocysteine to cysteine in S

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Risk Bias The Cochrane ROB-2 tool assesses risk of bias in randomized trials across five domains, including the randomization process, deviations from intended interventions, missing outcome data, measurement of the outcome, and selection of the reported result [66]