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This leads to both targeted anti-inflammatory effects at injury sites (where IRR expression is highest) and broader systemic modulation of inflammation, as seen in reduced circulating cytokine levels and improved outcomes in models of widespread conditions like diabetic complications, neuropathy, colitis, and autoimmune diseases, without broadly impairing overall immunity or stimulating red blood cell production
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[DOI] [PubMed] [Google Scholar] 353.De Val, S
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