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Within the hexosamine pathway, glucose is initially phosphorylated to form fructose-6-phosphate, which is subsequently converted to glucosamine-6-phosphate by the enzyme fructose-6-phosphate aminotransferase (GFAT) ( 3.4 AGEs formation Chronic hyperglycemia promotes the nonenzymatic glycosylation of macromolecules, including proteins and lipids, resulting in the accumulation of AGEs (39)
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