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These genes included agouti signaling protein ( ASIP ), agouti related protein ( AGRP ), and resistin ( RETN ) in the skeletal muscle
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CYP2E1-induced overproduction of ROS damages components of the respiratory chain—especially complexes I and III—causing mitochondrial membrane depolarization, cytochrome c release, and the activation of the intrinsic apoptotic pathway in hepatocytes [28]
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