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Once the acute group was excluded from analysis, the LC group displayed a more distinct metabolome profile compared to the HC and R groups ( Figures 2C, D )
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In people with obesity, 36 weeks of orforglipron (doses ranging from 12 to 45 mg in a phase 2 trial) resulted in a dose-dependent WL up to โ14.7% compared to โ2.3% with placebo, with concomitant improvement in cardiometabolic risk factors (Table 2) [25]
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