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Insomnia was the most common side effect seen with drugs that target the monoamine systems (such as sibutramine, bupropion, and tesofensine)
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π¬ What researchers observed in obese mice: β’ Less body-weight and fat-mass gain β’ Improved glucose tolerance and insulin sensitivity β’ Reduced hyperinsulinemia β’ Improvement in fatty-liver findings β’ No reduction in food intake in the studied animals These findings make NNMT inhibition an interesting metabolic research targetβbut they remain preclinical animal findings, not proven human results
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