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Efficacy and safety of once-weekly cagrilintide–semaglutide (CagriSema) in adults with type 2 diabetes inadequately controlled on diet and exercise (REIMAGINE 1): a randomised, double-blind, placebo-controlled, phase 3a study - The Lancet Diabetes

This synaptic imbalance extends to neuroinflammation and redox dysregulation, as SHANK3 mutations increase nitrosative stress markers (e.g., S-nitrosylated proteins) and proinflammatory cytokines, such as IL-6, further exacerbating circuit hyperexcitability [123],[124]

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They can also lower TNF-α, IL-1β, IL-6 levels, achieving anti-inflammatory effects by inhibiting the activation of inflammatory pathways