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Marked decreases in glial cell line-derived neurotrophic factor (GDNF) were also observed in TLR2-deficient and microbiota-depleted mice, whereas supplementation with GDNF or TLR2 agonist restored the ENS function, indicating that both are prerequisites for ensuring the integrity of ENS ( 3.3 Neurotoxic effects Clinical studies ( Bifidobacterium , Faecalibacterium prausnitzii , and Roseburia , while promoting opportunistic pathogens such as Clostridium and Streptococcus (Pinart et al., 2021)
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