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This has been demonstrated in lung cancer mouse models, chromophobe renal cell carcinoma and colorectal cancer
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Given that the status of these micronutrients in patients with T2DM is already likely to be suboptimal and that these deficiencies are variously associated with diabetic complications such as compromised endothelial, microvascular, vascular and neurological function, 38,43,46–49,80,85,95–97 it may be appropriate to consider supplementation where appropriate to mitigate these negative impacts of metformin
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