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Oligodendrocytes also accumulate sphingomyelin and GalCer and C22:0, C24:0 and C24:1 ceramides are found in oligodendrocytes (Hammerschmidt and Brüning, 2022) (Figure 1)

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Hyperinsulinemia can drive the ovaries to produce excessive testosterone in some women and disrupt other key hormones—luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol, and progesterone—perpetuating a self-reinforcing cycle of reproductive and metabolic dysfunction.[9][2][3] Reducing both fasting and postprandial insulin levels therefore improves PMOS across multiple domains