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KDIGO defines initial hyporesponsiveness as having no increase in hemoglobin concentration after the first month of appropriate weight-based dosing, and acquired hyporesponsiveness as requiring two increases in ESA doses up to 50% beyond the dose at which the patient had originally been stable

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Volume:500mg

5 Thus, the two-edged trait of ROS allows for the exertion of survival or death of cancer cells based on the intracellular levels of ROS