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difficile infection • Rare: Interstitial nephritis, liver enzyme elevation Drug Interactions • PPIs may reduce absorption of drugs requiring acidic pH (e.g., ketoconazole, atazanavir) • Omeprazole may inhibit CYP2C19, affecting clopidogrel activation • Mechanism: irreversible H⁺/K⁺ ATPase inhibitor • More potent than H2 blockers • Common indications: GERD, peptic ulcer, H
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