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As a GSTP1 inhibitor, NBDHEX binds to the H site of GSTP1, forcing GSTP1 to be released from JNK protein, thereby inducing subsequent JNK phosphorylation, leading to tumor cell cycle arrest and apoptosis [163]
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A recent study showed that the antioxidant signaling of OPCs is regulated by miR-146b-5p, enhancing the activation of Nrf2 signaling, which attenuates apoptosis and ROS production (Li et al., 2019)
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