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When mast cells become overactivated, they release enzymes such as tryptase and chymase that break down the proteins that hold intestinal cells tightly together
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Activation of SLC7A11 expression enables cells to restore redox homeostasis and maintain survival under stressful conditions such as oxidative stress, amino acid starvation, metabolic stress, and genotoxic stress (Koppula et al., 2018)
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