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Similarly, infusion of a lipid emulsion completely reversed the glucose lowering effect of leptin [19], suggesting that depleted glycerol may contribute but depleted fatty acids may play a larger role in the anti-diabetic effect of leptin

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See a doctor if: The darkening has a velvety or thickened texture — this may be acanthosis nigricans, associated with insulin resistance Darkening appeared suddenly and covers multiple skin folds on the body There is significant itching, burning, or odor alongside the darkening The area does not respond at all to topical treatment after 12+ weeks of consistent use 3 Common Mistakes Mistake #1: Treating Only the Skin, Not the Friction If tight clothing or bare-thigh rubbing continues daily, topical treatment is constantly fighting new pigmentation while trying to fade existing marks

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