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At maintenance doses of 2.0mg or 2.4mg, the volume increases significantly
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GSTM2 has been shown to be expressed in the substantia nigra of the human brain and exhibits a neuroprotective role by efficiently catalyzing the GSH-conjugation of ortho-quinone metabolite of dopamine, thereby protecting against its toxicity, redox cycling, and apoptosis, processes that have been associated with PD and schizophrenia [146]
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