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Unlike alanine and aspartate aminotransferases, GSTs are quickly and robustly released from cetrilobular and periportal hepatocytes after APAP overdose

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In addition, the classical ferroptosis inducer erastin was also reported to damage cardiomyocytes by initiating ferroptosis, while ENPP2, a lipid kinase generating the lipid mediator lysophosphatidic acid, could protect cardiomyocytes from the erastin-induced ferroptosis by decreasing ROS generation [107]

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