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The authors proposed that FK A can exert anti-inflammatory, pro-apoptotic, and anti-angiogenic effects by inhibiting the overactivation of PI3K/Akt and NF-κB signaling pathways, ultimately inhibiting the progression of endometriosis.163 Gamma Oryzanol Gamma oryzanol (GO, Figure 6) is mainly found in rice bran and rice bran oil.164,165 Gamma oryzanol has abundant biological activities, including antioxidant165,166 and anti-inflammatory.167 Eisalou et al demonstrated that GO decreased steroidogenic factor 1 (SF1) expression and upregulated BECN1 expression in autologous transplanted rat endometriotic lesions.168 SF1, also known as NR5A1, is an orphan nuclear receptor, and there is no clear natural ligand for SF1