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Moreover, the acidic assay conditions (pH 3.6) can precipitate proteins (e.g., milk casein) and generate pro-oxidant Fe 2+ ions, which may propagate radical chain reactions (Benzie and Strain, 1999
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It has been shown that microglia exposed to LPS displayed a primed phenotype with heightened levels of inflammatory markers such as iNOS, IL-1β, and p65, which were accompanied by iron deposits and ferroptosis (41)
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