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The Mayo Clinic explains that when stressors are always present, the fight-or-flight response stays switched on, and long-term exposure to cortisol can disrupt sleep, change immune responses, and suppress digestion, according to Mayo Clinic guidance on chronic stress

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We further observed that 85.7% (3,189/3,720) of the variants predicted to be damaging, including 2,866 missense SNVs and 323 LoF SNVs, were either only present in cases or more frequent in cases when compared to ASC controls (Figure 2)