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When researchers ran GHK data through the Broad Institute’s gene-expression maps, the molecule looked like it shifted the activity of several thousand human genes, on the order of a third of the protein-coding genome in that reference set
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Mechanistic studies have revealed that altered expression of iron metabolism-related proteins (including GPX4, FTH1, TfR1, and HO-1), accumulation of lipid peroxidation products, and disruption of antioxidant defense systems (particularly the Nrf2/GPX4 pathway) are central to ferroptosis progression in cardiac tissue
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