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As predicted, prolonged rapamycin treatment has been reported to impair Akt phosphorylation, the canonical downstream target of phosphorylation of mTORC2 (Sarbassov et al., 2006)
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At the cellular level, CSD can incite neuroinflammation through a series of interactions involving the pannexin-1 channel, caspase-1, interleukin (IL) 1β, and high-mobility group box 1 in neurons
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