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Table 1: Stimulation of primary chondrocytes and cartilage explants with IF-1β and TNFα mimic the in vivo pathological conditions by upregulating the expression of catabolic genes including IF-6, COX-2, iNOS, collagenases [matrix metalloprotease 13 (MMP-13)] and aggrecanases [a disintegrin and metalloproteinase with thrombospondin motif (ADAMTSs)] and by down regulating the expression of anabolic genes such as aggrecan and type II collagen [51–55]