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Interestingly, FMO3 is also the flavin monooxygenase responsible for the conversion of ( S )-nicotine to the trans -isomer of ( S )-nicotine N -1β²-oxide, which is excreted in the urine of smokers and those using a nicotine patch
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doi: 10.1016/j.enzmictec.2021.109808
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