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The Fat Loss Benefits: What the Trials Actually Show In the REDEFINE 1 Phase 3 trial, adults with obesity or overweight who received 2.4 mg of Cagrilintide once weekly lost an average of 11.8% of their body weight after 68 weeks, compared to just 2.3% in the placebo group

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weight loss plateau not reachedLimited sample size per dose groupNo direct comparison with semaglutide Safety, tolerability, pharmacokinetics, and pharmacodynamics of concomitant administration of multiple doses of cagrilintide with semaglutide 2.4 mg for weight management: a randomised, controlled, phase 1b trial Enebo LB, Berthelsen KK, Kankam M, Lund MT, Rubino DM, Satylganova A, Lau DCW (2021) • The Lancet Phase 1b trial evaluating safety, pharmacokinetics, and pharmacodynamics of cagrilintide (0.16-4.5 mg) co-administered with semaglutide 2.4 mg weekly for weight management