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On this basis, ferroptosis research in periodontitis should integrate single-cell sequencing with spatial transcriptomics (e.g., Stereo-seq) to construct high-resolution multi-omics maps, combined with clinical parameters (CBCT bone volume, bleeding on probing, clinical attachment loss) to identify susceptible cell subpopulations and map their spatiotemporal networks with osteoblasts, osteoclasts, and immune cells (125–128)

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For example, quercetin and luteolin act as metal ion chelators, binding Fe²⁺ and Cu²⁺, which catalyze ROS production, thereby reducing oxidative stress within melanocytes 141