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Itching that persists beyond one week or spreads significantly beyond the injection site suggests a possible allergic component rather than a simple irritant response

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Intranasal delivery sits in a clinical sweet spot: the nasal mucosa is rich in capillaries, the surface area is generous, and small peptides can be absorbed directly into systemic circulation — and, in some cases, transported along olfactory and trigeminal pathways toward the central nervous system

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