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GPX4 and FSP1 ( AIFM2 ) mutational status of TCGA tumour samples was retrieved from cBioPortal151 using the TCGA PanCancer Atlas collection ( For survival data, patients were stratified based on GPX4 or FSP1 expression and overall survival rates were plotted to compare patients with high- GPX4 or FSP1 expression (top 50% above median expression) with the rest of the cohort ( n = 464 patients)

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TDO activity is chiefly governed by the amino acid's level itself, and therefore its biological action is usually steady and not influenced by inflammatory mediators.77 During conditions of inflammation and increased oxidative stress, IDO activation in the extrahepatic tissues shifts the metabolism of tryptophan away from the liver