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it identified decreases in apolipoprotein A1 and transthyretin isoforms and increases in beta-hemoglobin, albumin fragments, and immunoglobulin fragments, with the immunoglobulin/albumin fragment spot showing a linear relationship with IGF-1 levels — consistent with downstream GH/IGF-1 axis engagement beyond a transient hormone spike, though the small uncontrolled cohort limits generalization

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This is the Perfect B supervised convention rather than a validated pharmacologic requirement: there is no evidence of pituitary downregulation on this timescale, and the pause is a conservative choice given the absence of long term human safety data

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