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Deactivation/Detoxification The most well-characterized example of the involvement of the mercapturate pathway in the metabolism of endogenous compounds relates to the sequential transformations of leukotrienes: LTA 4 → LTC 4 (glutathione S -conjugate) → LTD 4 (cysteinylglycine S -conjugate) → LTE 4 (cysteine S -conjugate) by the consecutive actions of LTC 4 synthase, γ-glutamyl leukotrienase, and cysteinylglycine dipeptidase (Ago et al., 2007, Hagmann et al., 1986, Heisterkamp et al., 2008, Murphy and Gijón, 2007, Örning et al., 1986, Veiga-da-Cunha et al., 2010)

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According to the CDC, excessive alcohol intake leads to an economic cost of $249 billion per year 15 , with most of the cost (72%) resulting from decreased productivity in the workplace, and 11% of the cost dedicated to health care expenses related to excessive drinking 16