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Disarrangements on the TJP location and/or expression that result in alterations in intestinal permeability have been found in inflammatory diseases, with stress being a risk factor that aggravates inflammatory conditions, as seen in irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD) [2,7,10,11,12]

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A published intragastric amount tells you the peptide survived the gut, which is consistent with its gastric origin, but it does not tell you what an equivalent intranasal amount would be