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Considerations for the genotoxicity assessment of middle size peptide drugs containing non-canonical amino acid residues | Genes and Environment | Springer Nature Link

Diluting that into an adult’s ~3 litres of plasma changes the arithmetic considerably, but the point stands: the vial format was designed around commercial convenience, not around any dose that the mechanistic literature identified as biologically relevant

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Copper may become potential irritants when they are oxidized and causes the formation of free acids