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For example, NMR-titration experiments of non-glutathionylated poplar GrxC4 or ScGrx8 with GSH required high glutathione concentrations to detect chemical shifts 47,48 (and titrations of active site serine mutants with GSSG cannot discriminate between both glutathionyl moieties)
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Additionally, genistein exhibits both proliferative (estrogenic) and antiproliferative (antiestrogenic) properties (11), and currently dietary supplements of genistein are widely used for menopausal symptoms by women as a potential alternative therapy (12)
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