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In addition, there is a worldwide trend toward legalization (e.g., in the United States and Canada) of recreational and medical use of cannabis and cannabis products, with new health concerns arising related to the increasing use of cannabis (188)

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In vitro studies have demonstrated that RCC cells exhibit high expression of both IGF-1 and IGFBP-3, which have opposing effects: inhibition of IGF-1 reduces RCC cell proliferation, while blocking IGFBP-3 increases it.39 This response occurs because IGF-1 signals through IGF1R triggering proliferative effects and promoting IGFBP-3 expression, the latter modulating the IGF-1 actions