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Thus, senescent cells are causal for the reduction in renal function in fast aging Xpd TTD/TTD and naturally aged wildtype mice and by selective targeting of high-SASP expressing senescent cells in the tubuli, FOXO4-DRI can restore kidney homeostasis

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In the human studies FDA identified — covering rectal, intra-articular, intravesical, and intravenous administration — no serious adverse events were reported, and the most common side effects were headache and flatulence at rates comparable to placebo