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Recently, we found that liver-specific knockout of a TGF-β/SMAD adaptor βII-spectrin (SPTBN1 LSKO) , blocks NASH and HCC, and βII-spectrin siRNA reverses NASH in human NASH 3D cultures ( Sci Transl Med
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Circ-PSNE1 was significantly upregulated in DR patients and in HG-treated ARPE-19 cells, and downregulation of circ-PSEN1 reduced cell death, decreased MDA and Fe 2+ content, and increased the expression of Gpx4 and solute carrier family 7 member 11 (SLC7A11)
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