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Chaperones attempt to remedy the unfolded protein first and, if unsuccessful, activate cellular programs, including the UPR, heat shock response (HSR), and ER-associated degradation (ERAD), to induce processes to either fix the problem or destroy the unfolded proteins (324, 325)
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[DOI] [PubMed] [Google Scholar] 117.Sun R, Wang YF, and Yang X (2024)
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