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The accumulation of α-syn in DA neurons into higher molecular pathological structures causes neurodegeneration, which further affects autophagy/lysosomal balance, mitochondrial homeostasis, ER, synaptic function, oxidative stress, and excitotoxicity [156]

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The symbiosis with the microbiota is established from birth and is rewired several times in the first years of life, a period during which children undergo rapid and irreversible growth, showing significant increases in height and weight, and their organs and cognitive abilities undergo great changes [349]