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An SD diet exacerbates weight loss, reduces colon length, and increases stool bleeding and diarrhea in models of DSS-induced colitis and in shPsat1 mice (short hairpin RNAs, shRNAs targeting the 2nd gene in the SSP pathway), consistent with worsened disease severity and inflammation 62,114

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This theory could plausibly explain the reduced concentrations of GABA observed in MRS studies of MDD, as well as the observations of reduced concentrations of GLX, a combined measure of glutamate and glutamine