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As mTORC2 has been previously suggested to directly regulate xCT (Gu et al., 2017), we utilized Rictor -/- MEFs, which lack mTORC2 activity, to determine whether mTORC2 was contributing to the decreased cystine uptake observed upon treatment with mTOR inhibitors
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Furthermore, MDA–protein adducts stimulate Th17 cells and promote the secretion of pro-inflammatory cytokines such as IL-6, IL-8, and IL-25
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