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Their rapid metabolism serves a dual purpose: it prevents these potent signaling molecules from acting systemically when they are intended to regulate local processes, and it generates more stable metabolites that provide accessible windows into whole-body eicosanoid production

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Acknowledgements The authors extend their appreciation to the Research, Development, and Innovation Authority (RDIA), Saudi Arabia, for funding this work through grant number (13385-Tabuk-2023-UT-R-3-1-SE)