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Nevertheless, many currently ongoing clinical trials are focused on inhibition of Pioglitazone, an agonist of peroxisome-proliferator-activated receptor gamma (PPARγ), acts on astrocytes and regulates metabolic coupling of astrocytes/neurons (Cowley et al., 2012), promotes the formation of dendritic spines and synapses (Moosecker et al., 2019), ameliorates amyloid and tau pathology in animal models (Singh, 2022), and improve learning and memory (Cowley et al., 2012)
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