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it downregulated the expression of Nav1.7 in calcitonin gene-related peptide (CGRP)-labeled sensory neurons of the DRG, and attenuated the upregulation of Nav1.7, thereby reducing the generation and transmission of nociceptive signals, alleviating peripheral neuropathic pain, and further acting on mononeuropathy (Yang et al., 2022)
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A patient could be symptom-free on paper and still lose their apartment, their job, and their social world, not because the illness had won, but because the treatment had taken too much with it
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