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Glutathione peroxidase 4 (GPX4) pathway Lipid peroxidation is regulated by the selenoenzyme glutathione peroxidase 4 (GPX4), which transforms lipid hydroperoxides in phospholipid acyl chains into lipid alcohols, concurrently oxidizing reduced GSH to glutathione disulfide (GSSG) (Forcina and Dixon, 2019, Pope and Dixon, 2023)

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